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Cursus: NWI-MOL053
NWI-MOL053
Pharmacochemistry
Cursus informatieRooster
CursusNWI-MOL053
Studiepunten (ECTS)6
CategorieBA (Bachelor)
VoertaalEngels
Aangeboden doorRadboud Universiteit; Faculteit der Natuurwetenschappen, Wiskunde en Informatica; Moleculaire Wetenschappen;
Docenten
Docent
dr. T.J. Boltje
Overige cursussen docent
Docent
dr. K.M. Bonger
Overige cursussen docent
Contactpersoon van de cursus
prof. dr. F.G.M. Russel
Overige cursussen docent
Docent
prof. dr. F.G.M. Russel
Overige cursussen docent
Coördinator
prof. dr. F.G.M. Russel
Overige cursussen docent
Collegejaar2016
Periode
KW1  (29-08-2016 t/m 06-11-2016)
Aanvangsblok
KW1
Onderwijsvorm
voltijd
Opmerking-
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersJa
VoorinschrijvingNee
WachtlijstNee
Plaatsingsprocedure-
Cursusdoelen

After this course, the student is able to:

  • explain the effect as well as the fate of drugs in the human body from the point of view of molecular targets and mode of action
  • understand and apply the techniques and methods of pharmacochemistry that are operative in the development of new drugs
  • describe the relationship between structure and activity of drugs both in a qualitative and quantitative manner.
Inhoud

Pharmocochemistry (medicinal chemistry) comprises a multidisciplinairy field that focuses on the relationship between chemical structure and biological activity of drugs at a molecular level. An important target of pharmacochemistry is the development of new drugs and other biologically active substances. In order to develop a new drug, medicinal chemists are involved in the design, organic synthesis, structural elucidation and pharmacological-toxicological research of biologically active compounds.
This course will discuss the fundamental principles underlying the mode of action and metabolism of drugs in the human body. Apart from that, an overview will be provided of the specific methods applicable for design, synthesis and optimization of new drugs, with particular focus on the relationship between structure and activity. Topics that will be discussed:

  • drug development process - role of pharmacochemistry
  • receptor pharmacology
  • dose-response relationships
  • pharmacokinetics
  • absorption, distribution, biotransformation and excretion
  • pharmacogenetics
  • molecular design strategies
  • (quantitative) structure-activity relationships
  • computer-assisted drug design
  • combinatorial chemistry
  • drugs acring on the nervous system
  • antibiotics and cytostatics
Bijzonderheden
This course will be taught in EnglishContact: prof.dr. F.G.M. Russel, email: Frans.Russel@radboudumc.nl
Toetsinformatie
Written exam (75%) and oral presentation (25%)
Voorkennis
This is a course in the programme 'Molecular life sciences'.Structure of atoms and molecules (NWI-MOL079), Reactions and kinetics (NWI-MOL007).The course is open to students molecular life sciences, chemistry, natural sciences and biology. A prerequisite for biology students is chemical knowledge at the level of chapters 1-8, 16, 18 and 23 of Maitland Jones' Organic Chemistry (3rd Edition, available in the library's study section), or the course NWI-MOL101 Essentials of molecular chemistry
Literatuur
Necessary:Graham L. Patrick, An Introduction to Medicinal Chemistry, Fifth Edition, OXFORD University Press, ISBN 978-0-19-969739-7, January 2013
Werkvormen

• 20 hours computer course
• 20 hours lecture
• 8 hours student presentation
• 9 hours question session
• 16 hours problem session
• 95 hours individual study period
Verplicht materiaal
Boek
Graham L. Patrick, An Introduction to Medicinal Chemistry, Fifth Edition, OXFORD University Press, January 2013
ISBN:9780199697397
Werkvormen
Computerpracticum

Hoorcollege

Overig/Onbekend

Project

Responsiecollege

Werkcollege

Zelfstudie

Toetsen
Tentamen
Weging1
GelegenhedenBlok KW1, Blok KW2

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