After this course the student is able to:
- establish a relationship between exposure to xenobiotics, including drugs, and the resulting distortions of molecular and physiological processes and health risks to humans
- describe the role of biotransformation of xenobiotic substances in relation to toxification, detoxification and mechanisms of distribution and excretion
- describe the toxicity of some important groups of xenobiotics and explain how the toxic effects on cellular / molecular processes can manifest themselves in the whole organism
- uderstands the structure-activity relationship (SAR) for some groups of toxic substances
Toxicology ("science of poisons") focuses on studying the harmful effects of substances on living organisms. The aim is to assess and minimize undesirable effects the risks of exposure to these substances to humans, animals and the environment. Toxicology is an interdisciplinary science that studies the mechanism of poisoning, making use of chemistry, biology, genetics, physiology and medicine. In this course the student will understand basic concepts of toxicology, such as exposure, dose-response relationships, biotransformation, and kinetics.
In addition, the molecular mechanisms and problems of some specific groups of contaminants (eg pesticides, stimulants, natural toxins, PAHs, PCBs and dioxins) will be addressed. Moreover, the mechanisms of toxicity on organ systems such as liver, kidney, lungs, blood, reproductive organs, and the central and peripheral nervous system will be discussed. During the course the students will use "the expert knowledge base" system (Derek) that predicts the toxicity based on structural properties of compounds.
|This course will be taught in EnglishContact: dr. J.B. Koenderink, tel. 024-3613654.|
|Written examination and report. The exam provides 70% of the final mark and must be at least 5.0.|
|The course is open for students Molecular life sciences, Chemistry, Physics, and Biology. |
Some Fundamental knowledge of chemistry (e.g. though the course NWI-MOL101 Essentials of molecular chemistry), cell biology, biochemistry and (patho) physiology will be assumed.
This is a course in the programme 'Molecular Life Sciences'.
• John A. Timbrell, Principles of Biochemical Toxicology, 4e editie, 2009, uitgever Informa Healthcare, ISBN-10: 0-8493-7302-6 ISBN-13: 978--0-8493-7302-2.
• 10 hours computer course
• 16 hours lecture
• 20 hours group project work without guidance
• 10 hours question session
• 10 hours problem session
• 78 hours individual study period
|John A. Timbrell, Principles of Biochemical Toxicology, 4e editie, 2009, uitgever Informa Healthcare|
|Gelegenheden||Blok KW3, Blok KW4|