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Cursus: NWI-MOL411
NWI-MOL411
Protein Modification
Cursus informatieRooster
CursusNWI-MOL411
Studiepunten (ECTS)3
CategorieMA (Master)
VoertaalEngels
Aangeboden doorRadboud Universiteit; Faculteit der Natuurwetenschappen, Wiskunde en Informatica; Moleculaire Wetenschappen;
Docenten
VorigeVolgende 2
Docent
dr. T.J. Boltje
Overige cursussen docent
Contactpersoon van de cursus
dr. K.M. Bonger
Overige cursussen docent
Coördinator
dr. K.M. Bonger
Overige cursussen docent
Docent
dr. K.M. Bonger
Overige cursussen docent
Docent
dr. J. Mecinovic
Overige cursussen docent
Collegejaar2016
Periode
KW3  (30-01-2017 t/m 09-04-2017)
Aanvangsblok
KW3
Onderwijsvorm
voltijd
Opmerking-
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersJa
VoorinschrijvingNee
WachtlijstNee
Plaatsingsprocedure-
Cursusdoelen

After completion of this course you will be able to

  • Describe the most common post-translational protein modifications and their biological functions
  • Describe the molecular details of (bio)chemical methods to introduce or modify (artificial) post-translational modifications and how these are used to answer specific biological questions
  • Know the analytical methods used in the field of chemical biology and apply them in the correct context to study protein (post-translational) modifications
  • Read, understand and present relevant scientific literature aimed to study post-translational modifications with the use of chemical (biology) approaches
  • Compose a creative, well-explained and thoroughly-thought research proposal for a relevant biological question related to the post-translational protein modification by methods discussed during the lectures.
Inhoud

Proteins are modified in several ways after ribosomal translation. Post-translational modifications include trimming, splicing, phosphorylation, glycosylation, oxidation, addition of membrane anchors, fusion with other proteins, alkylation, acetylation, and many other types of modification. As a result of such modifications, the potential diversity of the proteome, the complete collection of all proteins in a cell, tissue or organism, greatly exceeds the number of genes in the genome. Proteomes vary considerably between different cell types and tissue samples from the same organism. Chemical biology seeks to understand such differences.
In this course several types of post-translational modifications, methods to study such modifications and technologies to manipulate proteins based upon such modifications will be introduced.

Bijzonderheden
This is an obligatory course for Netherlands Research School for Chemical Biology (NRSCB) students. The course is focussed on chemical biology approaches to understand and study post-translational modifications and might have some overlap with Chemical Biology (NWI-MOL401). There is no scheduled exam; the final mark is based on the literature presentation and the quality of the research proposal.Contact: dr. Kimberly Bonger, 024-3652535, K.bonger@science.ru.nl
Onderwerpen
• Introduction to post-translational modifications
• Glycosylation
• Protein modification in epigenetic regulation
• Protein splicing
• Manipulation of protein expression levels (degrons)
• Fusion proteins and detection
Toetsinformatie
There is no scheduled written exam; the final mark is based on the quality of a literature presentation and a research proposal.
Voorkennis
Bachelor in Chemistry or Molecular Life Sciences. The course contains aspects of both organic chemistry and biochemistry.
Literatuur
Handouts; scientific (review) papers
Werkvormen

• 2 hours guided group project work
• 12 hours lecture
• 10 hours group project work without guidance
• 5 hours student presentation
• 8 hours problem session
• 47 hours individual study period
Extra information teaching methods: The course is scheduled within a two-weeks period. The first week is filled with lectures/tutorials and literature presentations. The second week is scheduled for composing a research proposal. The student should be present at all lectures/tutorials and literature presentations in the first week.
Verplicht materiaal
Artikelen
Scientific (review) papers
Handouts
Handouts
Werkvormen
Cursus
AanwezigheidsplichtJa

Algemeen
The student should be present at all lectures/tutorials and literature presentations in the first week.

Hoorcollege
AanwezigheidsplichtJa

Overig/Onbekend
AanwezigheidsplichtJa

Project
AanwezigheidsplichtJa

Werkcollege
AanwezigheidsplichtJa

Zelfstudie
AanwezigheidsplichtJa

Toetsen
Tentamen
Weging1
ToetsvormTentamen
GelegenhedenBlok KW3, Blok KW4

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