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Cursus: NWI-NM103B
NWI-NM103B
Methods in Neuroscience
Cursus informatieRooster
CursusNWI-NM103B
Studiepunten (ECTS)3
CategorieMA (Master)
VoertaalEngels, Nederlands
Aangeboden doorRadboud Universiteit; Faculteit der Natuurwetenschappen, Wiskunde en Informatica; Wiskunde, Natuur- en Sterrenkunde;
Docenten
Docent
prof. dr. F.P. Battaglia
Overige cursussen docent
Coördinator
prof. dr. A.J. van Opstal
Overige cursussen docent
Contactpersoon van de cursus
prof. dr. P.H.E. Tiesinga
Overige cursussen docent
Docent
prof. dr. P.H.E. Tiesinga
Overige cursussen docent
Docent
prof. dr. R.J.A. van Wezel
Overige cursussen docent
Collegejaar2016
Periode
KW2  (07-11-2016 t/m 29-01-2017)
Aanvangsblok
KW2
Onderwijsvorm
voltijd
Opmerking-
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersJa
VoorinschrijvingNee
WachtlijstNee
Plaatsingsprocedure-
Cursusdoelen
  1. Students can describe and compare different high-resolution neurophysiological techniques, and understand the strengths and limitations of the different techniques
  2. Students can motivate why a particular technique will be preferred for a given research question
  3. Students can interpret neural responses to sensory stimuli and behavioural responses obtained with the different techniques
  4. Students understand the physical-chemical principles of electrophsyiological recordings, of two-photon neuroimaging, and of optogenetics.
Inhoud

The course provides conceptual, methodological, and practical insights into the major high-resolution neurophysiological techniques that are used to probe and manipulate the function of local neural circuits in vivo and in vitro preparations, such as single-unit recordings, micro-stimulation, and local inactivation, patch clamping, multi-electrode recording arrays (MEA’s) and multi-unit data analysis (Battaglia), two-photon microscopy (Van Wezel), and optogenetics (Tiesinga).
Each method is explained in a 2 hr lecture, and illustrated by a key research paper, and covered in a two-hour computer practicum, in which experimental results obtained with the method are analysed and interpreted by the students as assignments (and a written report).

Bijzonderheden
This course is obligatory for all students enrolled in the FNWI Neuroscience Master Track.It is also open as an elective course for students from the Cognitive Neuroscience Research Master (track 4: Brain Networks and Neuronal Communication, and track 2: Perception, Action, and Control).
Onderwerpen
• Single-unit recording of neural activity in the living brain. Electrical microstimulation.
• Analysis of single-unit spike trains from the visual, oculomotor, and auditory systems. Spike-sorting algorithms, reverse correlation, extraction of receptive fields, sensorimotor encoding.
• Multi-electrode array electrophysiology; multi-unit data analysis; cross-correlation;
• Two-photon microscopy; structural two-photon analysis; functional two-photon microscopy
• Optogenetics
Toetsinformatie
Written exam (70%) and brief essays on results of computer practica (30%)
Voorkennis
Neurofysica 1 (WiNSt, Science), or Neurobiofysica (Bi), or equivalent
Systems Neuroscience (Master), Behavioural Neuroscience (Master)
Literatuur
A syllabus and a selection of modern research papers will be disseminated through Blackboard.
Werkvormen

• 16 hours computer course
• 16 hours lecture
• 8 hours question session
• 44 hours individual study period
Verplicht materiaal
Dictaat
A syllabus will be disseminated through Blackboard.
Artikelen
A selection of modern research papers will be disseminated through Blackboard.
Werkvormen
Cursus

Hoorcollege

Responsiecollege

Werkcollege

Zelfstudie

Toetsen
Tentamen
Weging1
GelegenhedenBlok KW2, Blok KW3

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