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Course module: NWI-BM010C
NWI-BM010C
Advanced Adaptation Physiology
Course infoSchedule
Course moduleNWI-BM010C
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Coordinator
prof. dr. G. Flik
Other course modules lecturer
Contactperson for the course
prof. dr. G. Flik
Other course modules lecturer
Lecturer
prof. dr. G. Flik
Other course modules lecturer
Lecturer
dr. M.H.A.G. Gorissen
Other course modules lecturer
Lecturer
dr. P.H.M. Klaren
Other course modules lecturer
Academic year2017
Period
KW1  (04/09/2017 to 12/11/2017)
Starting block
KW1
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims

The student can describe the following concepts and notions using his/her own words and with examples:

  1. The role of adaptation and acclimation in Darwin's theory of evolution;
  2. A “Panglossian paradigm”, the difference between an adaptation and an exaptation (according to Gould);
  3. What is the context of "adaptation" in Gould and Lewontin's theory of punctuated equilibrium;
  4. Phenotypical plasticity, the difference between adaptation and acclimation;
  5. General biochemical principles in the adaptation/acclimation of enzymes and membranes to changes in temperature;
  6. Fundamental physiology of calcium metabolism and calcitropic hormones;
  7. Consequences of (increased) body size on physiology and anatomy of organisms, using quantitative relationships (allometric power functions);
  8. Allometric coefficient in a power function and its interpretation
  9. Allostasis, or “constancy through change”
  10. Integration of evolutionary and physiological concepts in a symbiontic relationship.
Content

This series of lectures focuses on organismal physiology: regulatory mechanisms in the intact animal are addressed (Integrative Physiology). The central theme is how animals (including humans) have adapted to realise a dynamic interaction and to cope with continuously changing environmental conditions. Homeostatic and allostatic principles are discussed.

Students (in groups) will read a research paper and give a plenary oral presentation to their fellows.

The course content is centered around the themes:

  • Adaptation and evolution
  • Temperature adaptation
  • Allostasis
  • Allometry
  • Phenotypic plasticity
When appropriate, topics that received attention in recent papers and science sections of news papers will be addressed.
Literature
Zie Engelse beschrijving.
Teaching formats

• 16 hours lecture
• 2 hours question session
• 2 hours problem session
• 60 hours individual study period
Additional comments
contact: prof. dr. Gert Flik (g.flik@science.ru.nl)
Topics
• Adaptation and evolution
• Temperature adaptation
• Allostasis
• Allometry
• Phenotypic plasticity
Test information
The written exam consists of a selection of open questions on different topics.
Prerequisites
Acquaintance with the content of the Bachelor courses 'Adaptation Phyiology' and 'Endocrinology' is highly recommended, but not a strict requirement.
Required materials
Handouts
The lectures will be published as Powerpoint-handouts (without subtexts!) on Blackboard.
Recommended materials
Book
dedicated chapters in 'Sherwood Animal Physiology' and related textbooks as well as dedicated journal papers
Instructional modes
Course occurrence

Lecture

Response course

Tutorial

Zelfstudie

Tests
Tentamen
Test weight1
Test typeDigital exam with TAO
OpportunitiesBlock KW1, Block KW2

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