SluitenHelpPrint
Switch to English
Cursus: NWI-MOL137
NWI-MOL137
Cell Biophysics
Cursus informatieRooster
CursusNWI-MOL137
Studiepunten (ECTS)6
CategoriePB (Propedeuse)
VoertaalEngels
Aangeboden doorRadboud Universiteit; Faculteit der Natuurwetenschappen, Wiskunde en Informatica; Moleculaire Wetenschappen;
Docenten
Docent
dr. J. van Rhijn
Overige cursussen docent
Examinator
dr. D. Schubert
Overige cursussen docent
Docent
dr. D. Schubert
Overige cursussen docent
Coördinator
dr. D. Schubert
Overige cursussen docent
Contactpersoon van de cursus
dr. D. Schubert
Overige cursussen docent
Collegejaar2020
Periode
KW4  (05-04-2021 t/m 31-08-2021)
Aanvangsblok
KW4
Onderwijsvorm
voltijd
Opmerking-
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersJa
VoorinschrijvingNee
WachtlijstNee
Plaatsingsprocedure-
Cursusdoelen
Aims (leerdoelen)
  • Be familiar with the most relevant mechanisms that underlie the generation of action potentials in neurons and muscle cells (Cell Biophysics Project). 
  • Be familiar with the basic molecular and cellular mechanisms that underlie muscle physiology (Cell Biophysics Project). 
  • Understand how the passive and active membrane properties mediate communication between electrically active cells and, for muscle cells, recognize how this leads to controlled muscle contraction and relaxation (Cell Biophysics Project). 
  • Understand which main molecular mechanisms underlie distorted muscle control in context with skeletal muscle channelopathies (Cell Biophysics Project). 
  • Understand how at the molecular level the malfunction of ion channels eventually leads to the clinical symptoms of skeletal muscle channelopathies (Cell Biophysics Project). 
Inhoud
The aim of this course is to introduce students of molecular life sciences to cell biophysics, by means of bioelectricity. Bioelectricity is based on unequal distributions of ion over the plasma membrane. Due to the membrane’s specific and selective ion permeability a membrane potential is generated. The membranes of excitable cells, such as neurons or muscle cells contain voltage-dependent ion channels which enable the cells to generate an action potential. In this course we will discuss both the cell-physiological and the biophysical properties of the membrane potential and generation and transmission of the action potential. We will furthermore discuss the specific role and function of ion channels in regulating the membrane potential and excitability of cells. Eventually the students will use the acquired knowledge for interpreting molecular life sciences related problems. To this end we’ll focus on the clinical cases of inheritable skeletal muscle channelopathies. The background the students will acquire during the course will enable them to explain the causality between alterations on the molecular level all the way to the clinical phenotype. In a final patient demonstration with a clinician the MLW students as a group and interactively will diagnose a relevant patient case.  
 
General topics:
1.            What makes a cell “negative”? The membrane concept
2.            Active membrane properties and the action potential
3.            Muscles I: structure and function
4.            Muscles II: Muscular dysfunction due to Channelopathies

Instructional Modes
Niveau

Voorkennis

Toetsinformatie
The final grade for this course will be determined by: written test (80%) and lab report (20%). Both parts need to be 5.5 or higher.
Bijzonderheden

Verplicht materiaal
Witte jas en veiligheidsbril
Lab coat is needed for the Wet lab part of the course
Syllabus
The syllabus for the course will be provided electronically via Brightspace
Kosten:0,00
Aanbevolen materiaal
Boek
Text book "Purves: Neuroscience 5th edition (or newer)" is recommended for background reading
ISBN:9781605358413
Werkvormen
Computerpracticum
AanwezigheidsplichtJa

Hoorcollege

Practicum
AanwezigheidsplichtJa

Project
AanwezigheidsplichtJa

Werkcollege
AanwezigheidsplichtJa

Toetsen
Digital Exam
Weging4
ToetsvormDigitale toets met CIRRUS
GelegenhedenBlok KW4, Blok KW4

Verslag
Weging1
ToetsvormVerslag
GelegenhedenBlok KW4, Blok KW4

SluitenHelpPrint
Switch to English